Contemporary mafias in all their manifestations are now a transnational phenomenon. It is impossible to isolate mafia criminal activities in a single specific territory. To understand the new organized crime, it is necessary to have a complete picture to foresee the links and connections on a global level. The mafia criminal networks now all operate beyond the borders and must therefore be studied and fought worldwide. It is essential to reinvigorate investigative and judicial cooperation in the fight against transnational organized crime, and in terms of experience, Italy has a lot to offer both at a European and an international level. It is also desirable to create a global platform for the exchange of research and study experiences on the prevention and fight against organized crime.